Search Ontology:
ChEBI
SB-743921
- Term ID
- CHEBI:231716
- Synonyms
-
- GSK 743921
- GSK-743921
- GSK-921
- GSK743921
- N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl]-4-methylbenzamide
- N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxochromen-2-yl)-2-methylpropyl]-4-methylbenzamide
- SB 743921
- SB-743921 free base
- SB-921
- SB743921
- Definition
- A chromone that is 4H-chromen-4-one substituted by (1R)-1-[(3-aminopropyl)(4-methylbenzoyl)amino]-2-methylpropyl, benzyl, and chloro groups at positions 2, 3, and 7, respectively. It is a potent inhibitor of kinesin spindle protein (Ki = 0.1 nM) and exhibits antineoplastic activity.
- References
-
- cas:618430-39-0
- drugbank:DB05546
- lincs.smallmolecule:LSM-45775
- pdb-ccd:6LX
- pmc:PMC10129510
- pubmed:20461380
- pubmed:23394180
- pubmed:23875972
- pubmed:24950801
- pubmed:25146433
- pubmed:25665464
- pubmed:25772758
- pubmed:25860245
- pubmed:27379929
- pubmed:34384498
- pubmed:34925377
- pubmed:36273620
- pubmed:37523792
- pubmed:37894278
- pubmed:38265238
- pubmed:39000337
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from SB-743921
Phenotype where environments contain SB-743921
Phenotype modified by environments containing SB-743921
Phenotype affecting SB-743921
Human Disease Model