capivasertib

Term ID

CHEBI:229222

Synonyms

(S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
AZD 5363
AZD-5363
AZD5363
Truqap

Definition

An aminopiperidine that is piperidine substituted by 7H-pyrrolo[2,3-d]pyrimidin-4-yl, amino, and [(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]aminocarbonyl groups at positions 1, 4, and 4, respectively. It is a pan-AKT kinase inhibitor used in combination with fulvestrant for the treatment of adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, locally advanced or metastatic breast cancer with one or more PIK3CA/AKT1/PTEN-alterations.

References

cas:1143532-39-1
drugbank:DB12218
hmdb:HMDB0248786
kegg.drug:D11371
pdb-ccd:0XZ
pmc:PMC10431131
pubmed:22294718
pubmed:23394218
pubmed:29084756
pubmed:29242354
pubmed:31836609
pubmed:32205016
pubmed:32359497
pubmed:32359498
pubmed:32461793
pubmed:34837233
pubmed:35398754
pubmed:35490666
pubmed:35688662
pubmed:36508589
pubmed:36519303
pubmed:36572571
pubmed:36714540
pubmed:37093249
pubmed:37224269
pubmed:37256976
pubmed:37311901
pubmed:37328269
pubmed:37449963
pubmed:37543694
pubmed:37574619
pubmed:37596288
pubmed:37726304
pubmed:37803350
pubmed:38096965
pubmed:38388873
pubmed:38396173
pubmed:38396318
pubmed:38412269
pubmed:38566315
pubmed:38592948
wikipedia.en:Capivasertib

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from capivasertib

Phenotype where environments contain capivasertib

Phenotype modified by environments containing capivasertib

Phenotype affecting capivasertib

Human Disease Model