batimastat

Term ID

CHEBI:195398

Synonyms

• (2R,3S)-N(4)-hydroxy-N(1)-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide
• (2R,3S)-N(4)-hydroxy-N(1)-[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]-2-(2-methylpropyl)-3-[(thiophen-2-ylsulfanyl)methyl]butanediamide
• 4-(N-hydroxyamino)-2R-isobutyl-3S-(thiopen-2-ylthiomethyl)-succinyl-L-phenylalanine-N-methylamide
• batimastat
• batimastatum
• BB 94
• BB-94
• BB94

Definition

A secondary carboxamide resulting from the formal condensation of the carboxy group of (2S,3R)-5-methyl-3-{[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-2-[(thiophen-2-ylsulfanyl)methyl]hexanoic acid with the amino group of hydroxylamine. It a broad-spectrum matrix metalloprotease inhibitor.

References

• CAS:130370-60-4
• Chemspider:4515033
• DrugBank:DB03880
• KEGG:D03061
• LINCS:LSM-6276
• MetaCyc:CPD-21519
• PDBeChem:BAT
• PMID:10100701
• PMID:10416010
• PMID:10566008
• PMID:10628317
• PMID:11129784
• PMID:11435723
• PMID:11575928
• PMID:11718018
• PMID:12172929
• PMID:14741217
• PMID:15206921
• PMID:22684055
• PMID:24819550
• PMID:26443597
• PMID:26546696
• PMID:26559179
• PMID:28417261
• PMID:32048249
• PMID:32397419
• PMID:32411205
• PMID:33330030
• PMID:34055088
• PMID:34060428
• PMID:36001659
• PMID:36482856
• PMID:36825288
• PMID:37302822
• PMID:7577999
• PMID:7627972
• PMID:8062271
• PMID:8347186
• PMID:8610113
• PMID:8665519
• PMID:8913271
• PMID:8913840
• PMID:9816289
• PMID:9882797
• PMID:9932102
• Wikipedia:Batimastat

Ontology

ChEBI  ( EBI )