SYC-435

Term ID

CHEBI:189826

Synonyms

• 1-hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone
• 1-hydroxy-4-methyl-6-benzyl-2(1H)-pyridone
• 6-benzyl-1-hydroxy-4-methyl-1,2-dihydropyridin-2-one
• 6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one
• 6-benzyl-1-hydroxy-4-methylpyridin-2-one
• 6-benzyl-4-methyl-1-hydroxypyridin-2(1H)-one
• SYC 435
• SYC435
• TC-E 5008

Definition

A cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and benzyl groups, respectively. It is a potent inhibitor of mutant isocitrate dehydrogenase 1 (Ki values of 190 nM against R132H mutant and 120 nM against R132C mutant).

References

• cas:50405-58-8
• chemspider:14787404
• pdb-ccd:1BZ
• pmc:PMC6847717
• pubmed:23795241
• pubmed:25271760
• pubmed:29089260
• pubmed:31910018
• pubmed:35182954

Ontology

ChEBI  ( EBI )