Search Ontology:
ChEBI
AZ3451
- Term ID
- CHEBI:189647
- Synonyms
-
- 2-(6-bromo-1,3-benzodioxol-5-yl)-N-(4-cyanophenyl)-1-[(1S)-1-cyclohexylethyl]-1H-benzimidazole-5-carboxamide
- AZ 3451
- AZ-3451
- Definition
- A member of the class of benzimidazoles that is 1H-benzimidazole substituted by (1S)-1-cyclohexylethyl, 6-bromo-1,3-benzodioxol-5-yl, and 4-(cyanoanilino)acyl groups at positions 1, 2 and 5, respectively. It is an allosteric modulator of protease-activated receptor 2 (IC50 = 23 nM) and exhibits anti-osteoarthritis properties.
- References
-
- cas:2100284-59-9
- chemspider:59053349
- pdb-ccd:8UN
- pubmed:28445455
- pubmed:29457894
- pubmed:29798827
- pubmed:31841119
- pubmed:33242065
- pubmed:34307771
- pubmed:34590836
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from AZ3451
Phenotype where environments contain AZ3451
Phenotype modified by environments containing AZ3451
Phenotype affecting AZ3451
Human Disease Model