narlaprevir

Term ID

CHEBI:173104

Synonyms

• (1R,2S,5S)-3-[N-({1-[(tert-butylsulfonyl)methyl]cyclohexyl}carbamoyl)-3-methyl-L-valyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxoheptan-3-yl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
• (1R,2S,5S)-3-{(2S)-2-[({1-[(tert-butylsulfonyl)methyl]cyclohexyl}carbamoyl)amino]-3,3-dimethylbutanoyl}-N-[(3S)-1-(cyclopropylamino)-1,2-dioxoheptan-3-yl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
• (1R,2S,5S)-N-[(3S)-1-(cyclopropylamino)-1,2-dioxoheptan-3-yl]-6,6-dimethyl-3-[3-methyl-N-({1-[(2-methylpropane-2-sulfonyl)methyl]cyclohexyl}carbamoyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide
• Arlansa
• narlaprevir
• narlaprevirum
• SCH 900518
• SCH-900518
• SCH900518

Definition

An azabicyclohexane that is (1R,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane substituted by [(3S)-1-(cyclopropylamino)-1,2-dioxoheptan-3-yl]aminoacyl and N-({1-[(tert-butylsulfonyl)methyl]cyclohexyl}carbamoyl)-3-methyl-L-valyl groups at positions 2S and 3, respectively. It is a hepatitis C virus (HCV) NS3/4A serine protease inhibitor (Ki = 6 nM) that is used for the treatment of chronic hepatitis C.

References

• cas:865466-24-6
• chemspider:10031710
• drugbank:DB14760
• kegg.drug:D09644
• lincs.smallmolecule:LSM-45473
• pdb-ccd:NNA
• pubmed:20308381
• pubmed:20938912
• pubmed:21473061
• pubmed:21627104
• pubmed:22263860
• pubmed:23490393
• pubmed:24168257
• pubmed:24900178
• pubmed:25178998
• pubmed:27645244
• pubmed:32598756
• pubmed:33152262
• pubmed:33524017
• pubmed:33538596
• pubmed:33542181
• wikipedia.en:Narlaprevir

Ontology

ChEBI  ( EBI )