ferrostatin-1

Term ID

CHEBI:173086

Synonyms

3-amino-4-cyclohexylaminobenzoic acid ethyl ester
ethyl 3-amino-4-(cyclohexylamino)benzoate
Fer-1
ferrrostatin 1

Definition

An ethyl ester resulting from the formal condensation of the carboxy group of 3-amino-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation. It is also a radical-trapping antioxidant and has the ability to reduce the accumulation of lipid peroxides and chain-carrying peroxyl radicals.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: ethyl ester primary arylamine substituted aniline

ethyl ester primary arylamine substituted aniline Show first 5 Terms
has_role: antifungal agent antioxidant ferroptosis inhibitor neuroprotective agent radiation protective agent ... Show All 6 Terms

antifungal agent antioxidant ferroptosis inhibitor neuroprotective agent radiation protective agent radical scavenger Show first 5 Terms
inverse has_functional_parent: SRS11-92

SRS11-92 Show first 5 Terms

Phenotype

Phenotype resulting from ferrostatin-1

Phenotype where environments contain ferrostatin-1

Phenotype modified by environments containing ferrostatin-1

Human Disease / Model Data

Citations