SID 26681509

Term ID

CHEBI:167893

Synonyms

N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide
S-[2-(2-ethylanilino)-2-oxoethyl] 2-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-(1H-indol-3-yl)propanoyl]hydrazine-1-carbothioate
S-[2-(2-ethylanilino)-2-oxoethyl] 2-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-(1H-indol-3-yl)propanoyl]hydrazinecarbothioate
SID26681509
tert-butyl N-[(2S)-1-[2-[2-(2-ethylanilino)-2-oxoethyl]sulfanylcarbonylhydrazinyl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate

Definition

A carbohydrazide that is L-tryptophan in which the amino and carboxy groups are substituted by tert-butoxycarbonyl and 2-({[2-(2-ethylanilino)-2-oxoethyl]sulfanyl}carbonyl)hydrazinyl groups, respectively. It is a potent and reversible inhibitor of human cathepsin L (IC50 = 56 nM).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: carbohydrazide L-tryptophan derivative secondary carboxamide tert-butyl ester thioester

carbohydrazide L-tryptophan derivative secondary carboxamide tert-butyl ester thioester Show first 5 Terms
has_role: antiplasmodial drug cathepsin L (EC 3.4.22.15) inhibitor

antiplasmodial drug cathepsin L (EC 3.4.22.15) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from SID 26681509

Phenotype where environments contain SID 26681509

Phenotype modified by environments containing SID 26681509

Human Disease / Model Data

Citations