tesevatinib

Term ID

CHEBI:167674

Synonyms

7-{[(3aR,5R,6aS)-2-methyl-octahydrocyclopenta[c]pyrrol-5-yl]methoxy}-N-(3,4-dichloro-2-fluorophenyl)-6-methoxyquinazolin-4-amine
EXEL 7647
EXEL-7647
EXEL7647
KD 019
KD-019
KD019
N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-{[(3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl]methoxy}quinazolin-4-amine
tesevatinib
tesevatinibum
XL 647
XL-647
XL647

Definition

A member of the class of quinazolines that is quinazoline substituted by (3,4-dichloro-2-fluorophenyl)amino, methoxy, and [(3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl]methoxy groups at positions 4, 6 and 7, respectively. It is a multi-target tyrosine kinase inhibitor of EGFR, ErbB2, KDR, Flt4 and EphB4 and exhibits anti-cancer properties.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: aromatic ether dichlorobenzene diether monofluorobenzenes quinazolines ... Show All 7 Terms

aromatic ether dichlorobenzene diether monofluorobenzenes quinazolines secondary amino compound tertiary amino compound Show first 5 Terms
has_role: antineoplastic agent EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor epidermal growth factor receptor antagonist

antineoplastic agent EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor epidermal growth factor receptor antagonist Show first 5 Terms

Phenotype

Phenotype resulting from tesevatinib

Phenotype where environments contain tesevatinib

Phenotype modified by environments containing tesevatinib

Human Disease / Model Data

Citations