nucleocidin

Term ID

CHEBI:166872

Synonyms

• 4'-C-fluoroadenosine 5'-sulfamate
• 4'-fluoro-5'-O-sulfamoyladenosine
• 4'-fluoro-5'-O-sulphamoyladenosine
• [(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-fluoro-3,4-dihydroxyoxolan-2-yl]methyl sulfamate
• [(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-fluoro-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate
• [(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-2-fluoro-3,4-dihydroxyoxolan-2-yl]methyl sulfamate
• antibiotic T-3018
• T-3018

Definition

A nucleoside antibiotic that is 5'-O-sulfamoyladenosine in which the hydrogen atom at position 4' is replaced by a fluorine atom. It is a natural product synthesized by several Streptomyces species. It exhibits broad spectrum antibacterial activity, and also has a strong effect against Trypanosoma brucei, the protozoan parasite responsible for the African sleeping sickness.

References

• cas:24751-69-7
• chemspider:65250
• metacyc.compound:CPD-12712
• pubmed:1085509
• pubmed:1262649
• pubmed:13425454
• pubmed:13425455
• pubmed:13439466
• pubmed:13834368
• pubmed:24544578
• pubmed:26374477
• pubmed:27845468
• pubmed:28920128
• pubmed:30641108
• pubmed:32110306
• pubmed:5131149
• pubmed:5776261
• pubmed:5933868
• wikipedia.en:Nucleocidin

Ontology

ChEBI  ( EBI )

Resources

CTD