SG85

Term ID

CHEBI:147346

Synonyms

N-[(benzyloxy)carbonyl]-O-tert-butyl-L-seryl-N-{(2S,3E)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pent-3-en-2-yl}-L-phenylalaninamide
SG 85
SG-85

Definition

A secondary carboxamide resulting from the formal condensation of the carboxy group of N-[(benzyloxy)carbonyl]-O-tert-butyl-L-serine with the primary amino group of ethyl (2E,4S)-5-[(3S)-2-oxopyrrolidin-3-yl]-4-(L-phenylalanylamino)pent-2-enoate. It is a potent enterovirus 3C protease inhibitor with EC50 of 180 nM against enterovirus 71 (EV71) and 60 nM against human rhinovirus 14 in a live virus-cell-based assay.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: benzyl ester enoate ester ether ethyl ester L-phenylalanine derivative ... Show All 8 Terms

benzyl ester enoate ester ether ethyl ester L-phenylalanine derivative L-serine derivative pyrrolidin-2-ones secondary carboxamide Show first 5 Terms
has_role: anticoronaviral agent antiviral agent EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor

anticoronaviral agent antiviral agent EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from SG85

Phenotype where environments contain SG85

Phenotype modified by environments containing SG85

Human Disease / Model Data

Citations