remdesivir

Term ID

CHEBI:145994

Synonyms

(2S)-2-{(2R,3S,4R,5R)-[5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]phenoxy-(S)-phosphorylamino}propionic acid 2-ethyl-butyl ester
2-ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate
2-ethylbutyl N-[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]-L-alaninate
GS 5734
GS-5734
GS5734
remdesivir
remdesivirum

Definition

A carboxylic ester resulting from the formal condensation of the carboxy group of N-[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]-L-alanine with the hydroxy group of 2-ethylbutan-1-ol. A broad-spectrum antiviral prodrug with potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. It is currently in Phase III clinical trials for the treatment of Covid-19 in adults.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: aromatic amine C-nucleoside carboxylic ester nitrile phosphoramidate ester ... Show All 6 Terms

aromatic amine C-nucleoside carboxylic ester nitrile phosphoramidate ester pyrrolotriazine Show first 5 Terms
has_functional_parent: GS-441524

GS-441524 Show first 5 Terms
has_role: anticoronaviral agent antiviral drug prodrug

anticoronaviral agent antiviral drug prodrug Show first 5 Terms

Phenotype

Phenotype resulting from remdesivir

Phenotype where environments contain remdesivir

Phenotype modified by environments containing remdesivir

Human Disease / Model Data

Citations