sapacitabine

Term ID

CHEBI:145429

Synonyms

1-(2-cyano-2-deoxy-beta-D-arabinofuranosyl)-4-(hexadecanoylamino)pyrimidin-2(1H)-one
CS 682
CS-682
CS682
CYC 682
CYC-682
CYC682
N-(1-(2-cyano-2-deoxy-beta-D-arabinofuranosyl)-1,2-dihydro-2-oxo-4-pyrimidinyl)hexadecanamide
N-[1-(2-cyano-2-deoxy-beta-D-arabinofuranosyl)-2-oxo-1,2-dihydropyrimidine-4-yl]hexadecanamide
PCNDAC
sapacitabina
sapacitabine
sapacitabinum

Definition

A nucleoside analogue resulting from the formal condensation of the carboxy group of hexadecanoic acid with the amino group of CNDAC. It is the prodrug of CNDAC and is currently in clinical development for the treatment of acute myeloid leukemia (AML).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: nitrile nucleoside analogue secondary carboxamide

nitrile nucleoside analogue secondary carboxamide Show first 5 Terms
has_functional_parent: CNDAC hexadecanoic acid

CNDAC hexadecanoic acid Show first 5 Terms
has_role: antimetabolite antineoplastic agent DNA synthesis inhibitor prodrug

antimetabolite antineoplastic agent DNA synthesis inhibitor prodrug Show first 5 Terms

Phenotype

Phenotype resulting from sapacitabine

Phenotype where environments contain sapacitabine

Phenotype modified by environments containing sapacitabine

Human Disease / Model Data

Citations