praliciguat

Term ID

CHEBI:142431

Synonyms

• 1,1,1,3,3,3-hexafluoro-2-[({5-fluoro-2-[1-(2-fluorobenzyl)-5-(1,2-oxazol-3-yl)-1H-pyrazol-3-yl]pyrimidin-4-yl}amino)methyl]propan-2-ol
• IW-1973
• praliciguat
• praliciguatum

Definition

A member of the class of pyrazoles that is 5-fluoro-2-(1H-pyrazol-3-yl)pyrimidine which is substituted by a 2-fluorobenzyl group at position 1, 1,2-oxazol-3-yl group at position 5, and by a [3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propyl]nitrilo group at position 4. It is a soluble guanylate cyclase stimulator under clinical development for the treatment of heart failure with preserved ejection fraction.

References

• CAS:1628730-49-3
• PMID:29281143
• PMID:29643251
• Patent:WO2014144100
• Patent:WO2017095697
• Reaxys:27468841

Ontology

ChEBI  ( EBI )