nepicastat

Term ID

CHEBI:139334

Synonyms

• (S)-5-aminomethyl-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydroimidazole-2-thione
• 5-(aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-1,3-dihydro-2H-imidazole-2-thione
• nepicastat
• nepicastatum
• RS-25560-197
• SYN117

Definition

A member of the class of 1,3-dihydroimidazole-2-thiones that is 1,3-dihydro-2H-imidazole-2-thione in which one of the nitrogens is substituted by a 5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl group while the carbon adjacent to it is substituted by an aminomethyl group (the S enantiomer). It is a potent and selective inhibitor of both bovine and human dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine.

References

• CAS:173997-05-2
• DrugBank:DB12979
• PMID:11034950
• PMID:23289939
• PMID:23303068
• PMID:23561307
• PMID:25257286
• PMID:25602710
• PMID:9283721
• PMID:9641484
• Pubchem:9796181
• Reaxys:9425404
• Wikipedia:Nepicastat

Ontology

ChEBI  ( EBI )