atrasentan

Term ID

CHEBI:135810

Synonyms

(+)-A 127722
(+)-A-127722
(+)-A127722
(2R, 3R, 4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic acid
(2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic acid
(2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
A 147627
A-147627
ABT 627
ABT-627
ABT627
atrasentan
atrasentanum

Definition

A member of the class of pyrrolidines that is pyrrolidine substituted by 2-(dibutylamino)-2-oxoethyl, 4-methoxyphenyl, carboxy, and 1,3-benzodioxol-5-yl groups at positions 1, 2, 3, and 4, respectively (the 2R,3R,4S-stereoisomer). It is an endothelin endothelin type A receptor antagonist used to reduce proteinuria in adults with primary immunoglobulin A nephropathy.

References

cas:173937-91-2
drugbank:DB06199
pubmed:10610291
pubmed:11739244
pubmed:12193124
pubmed:17440096
pubmed:19717985
pubmed:25189702
pubmed:28230089
pubmed:30098343
pubmed:30198212
pubmed:30217875
pubmed:31982064
pubmed:31982065
pubmed:31982067
pubmed:32195223
pubmed:34853062
pubmed:34853063
pubmed:35119336
pubmed:35772861
pubmed:35892316
pubmed:37139863
pubmed:37157922
pubmed:37235521
pubmed:37657768
pubmed:37716952
pubmed:37820676
pubmed:37981428
pubmed:38969296
pubmed:39460694
pubmed:39503150
pubmed:39661119
pubmed:39798547
pubmed:39810771
pubmed:40245183
pubmed:40303226
wikipedia.en:Atrasentan

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from atrasentan

Phenotype where environments contain atrasentan

Phenotype modified by environments containing atrasentan

Phenotype affecting atrasentan

Human Disease Model