cycloguanil

Term ID

CHEBI:135029

Synonyms

1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine
1-(p-chlorophenyl)-4,6-diamino-2,2-dimethyl-1,2-dihydro-s-triazine
Chlorcycloguanil

Definition

A triazine in which a 1,6-dihydro-1,3,5-triazine ring is substituted at N-1 by a 4-chlorophenyl group, at C-2 and -4 by amino groups and at C-6 by gem-dimethyl groups. A dihydrofolate reductase inhibitor, it is a metabolite of the antimalarial drug proguanil.

References

cas:516-21-2
drugcentral:754
hmdb:HMDB0060974
pdb-ccd:1CY
pubmed:15228254
pubmed:29061131
pubmed:29882324
pubmed:6385887
pubmed:8494394
pubmed:9713549
reaxys:229760

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from cycloguanil

Phenotype where environments contain cycloguanil

Phenotype modified by environments containing cycloguanil

Phenotype affecting cycloguanil

Human Disease Model