OBO ID: GO:0060070
Term Name: canonical Wnt signaling pathway Search Ontology:
  • canonical Wnt receptor signaling pathway
  • canonical Wnt-activated signaling pathway
  • frizzled-1 receptor signaling pathway
  • Wnt receptor signaling pathway through beta-catenin
  • Wnt receptor signaling pathway via beta-catenin
  • Wnt receptor signalling pathway through beta-catenin
Definition: The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. (2)
Ontology: GO: Biological Process   QuickGO   AmiGO
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