| Term Name: |
canonical Wnt signaling pathway |
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Search Ontology:
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| Synonyms: |
- canonical Wnt receptor signaling pathway
- canonical Wnt-activated signaling pathway
- frizzled-1 receptor signaling pathway
- Wnt receptor signaling pathway through beta-catenin
- Wnt receptor signaling pathway via beta-catenin
- Wnt receptor signalling pathway through beta-catenin
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| Definition: |
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
(2)
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| References: |
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| Ontology: |
GO: Biological Process
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