OBO ID: CHEBI:176500

Term Name:	BAY11-7085		Search Ontology:
Synonyms:	(2E)-3-(4-tert-butylbenzene-1-sulfonyl)prop-2-enenitrile (2E)-3-[(4-tert-butylphenyl)sulfonyl]prop-2-enenitrile (2E)-3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2-propenenitrile (E)-3-(4-t-butylphenylsulfonyl)-2-propenenitrile (E)-3-(4-tert-butylphenylsulfonyl)-2-propenenitrile Bay 11-7083 Bay 11-7085 Bay-11-7085 BAY-117085
Definition:	A sulfone that is benzene substituted by [(E)-2-cyanoethenyl]sulfonyl and tert-butyl groups at position 1 and 4, respectively. It is an irreversible inhibitor of IkappaB-alpha phosphorylation in cells (IC50 = 10 muM) and prevents the activation of NF-kappaB.
References:	CAS:196309-76-9 Chemspider:4510087 LINCS:LSM-43815 PMID:14560113 PMID:15004016 PMID:16129475 PMID:16699956 PMID:16766531 PMID:16896168 PMID:17889719 PMID:22326395 PMID:23290051 PMID:25581261 PMID:26993765 PMID:28394395 PMID:29274359 PMID:30533198 PMID:30978702 PMID:32055188 PMID:32123585 PMID:34025434
Ontology:	ChEBI  ( EBI )