| Term: | pancreas PCNA complex |
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| Note: | This page represents a term created by the combination ("post-composition") of two ontology terms. For more information on the individual terms, click the hyperlinked name. |
| Name: | pancreas |
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| Synonyms: | |
| Definition: | The pancreas is an organ composed of endocrine and exocrine glandular tissue that produce hormones and digestive enzymes. Unlike in other studied vertebrates the pancreas in zebrafish develops from two buds, one anterior and one posterior. In adult fish the main pancreas is located on the right side attached to the lateral aspect of the intestine by the pancreatic duct. Typically, one large islet and 3-6 smaller islets occupy the main pancreas. The tail of the pancreas is embedded with single beta cells or clusters of small islets and extends caudally along the right side of the intestine. |
| Ontology: | Anatomy Ontology [ZFA:0000140] |
| Name: | PCNA complex |
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| Synonyms: | PCNA homotrimer, proliferating cell nuclear antigen complex, sliding clamp |
| Definition: | A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation. |
| Ontology: | GO: Cellular Component [GO:0043626] QuickGO AmiGO |