Term: heart canonical Wnt signaling pathway
Note: This page represents a term created by the combination ("post-composition") of two ontology terms. For more information on the individual terms, click the hyperlinked name.
Name: heart
Synonyms:
Definition: Blood pumping organ composed of four components: sinus venosus, atrium, cardiac ventricle and bulbus arteriosus.
Ontology: Anatomy Ontology [ZFA:0000114]
Name: canonical Wnt signaling pathway
Synonyms: canonical Wnt receptor signaling pathway, canonical Wnt-activated signaling pathway, frizzled-1 receptor signaling pathway, Wnt receptor signaling pathway through beta-catenin, Wnt receptor signaling pathway via beta-catenin, Wnt receptor signalling pathway through beta-catenin
Definition: A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Ontology: GO: Biological Process [GO:0060070]    QuickGO    AmiGO