Artola, M., Kuo, C.L., Lelieveld, L.T., Rowland, R.J., van der Marel, G.A., Codée, J.D.C., Boot, R.G., Davies, G.J., Aerts, J.M.F.G., Overkleeft, H.S. (2019) Functionalized cyclophellitols are selective glucocerebrosidase inhibitors and induce a bona fide neuropathic Gaucher model in zebrafish. Journal of the American Chemical Society. 141(10):4214-4218
|
Costa, R., Bellesso, S., Lualdi, S., Manzoli, R., Pistorio, V., Filocamo, M., Moro, E. (2020) A transcriptional and post-transcriptional dysregulation of Dishevelled 1 and 2 underlies the Wnt signaling impairment in type I Gaucher disease experimental models. Human molecular genetics. 29:285
|
Keatinge, M., Bui, H., Menke, A., Chen, Y.C., Sokol, A.M., Bai, Q., Ellett, F., Da Costa, M., Burke, D., Gegg, M., Trollope, L., Payne, T., McTighe, A., Mortiboys, H., de Jager, S., Nuthhall, H., Kuo, M.S., Fleming, A., Schapira, A.H., Renshaw, S.A., Highley, J.R., Chacinska, A., Panula, P., Burton, E.A., O'Neill, M.J., Bandmann, O. (2015) Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death. Human molecular genetics. 24(23):6640-52
|
Kim, G.J., Mo, H., Liu, H., Wu, Z., Chen, S., Zheng, J., Zhao, X., Nucum, D., Shortland, J., Peng, L., Elepano, M., Tang, B., Olson, S., Paras, N., Li, H., Renslo, A.R., Arkin, M.R., Huang, B., Lu, B., Sirota, M., Guo, S. (2021) A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons. eLIFE. 10:
|
Kuo, C.L., Kallemeijn, W.W., Lelieveld, L.T., Mirzaian, M., Zoutendijk, I., Vardi, A., Futerman, A.H., Meijer, A.H., Spaink, H.P., Overkleeft, H.S., Aerts, J.M.F.G., Artola, M. (2019) In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling. The FEBS journal. 286(3):584-600
|
Lelieveld, L.T., Mirzaian, M., Kuo, C.L., Artola, M., Ferraz, M.J., Peter, R.E.A., Akiyama, H., Greimel, P., van den Berg, R.J., Overkleeft, H.S., Boot, R.G., Meijer, A., Aerts, J.M.F.G. (2019) Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish. Journal of Lipid Research. 60(11):1851-1867
|
Su, Q., Schröder, S.P., Lelieveld, L.T., Ferraz, M.J., Verhoek, M., Boot, R.G., Overkleeft, H.S., Aerts, J.M.F.G., Artola, M., Kuo, C.L. (2021) Xylose-configured cyclophellitols as selective inhibitors for glucocerebrosidase. Chembiochem : a European journal of chemical biology. 22(21):3090-3098
|
Watson, L., Keatinge, M., Gegg, M., Bai, Q., Sandulescu, C., Vardi, A., Futerman, A.H., Schapira, A.H.V., Burton, E.A., Bandmann, O. (2019) Ablation of the pro-inflammatory master regulator miR-155 does not mitigate neuroinflammation or neurodegeneration in a vertebrate model of Gaucher's disease. Neurobiology of disease. 127:563-569
|
