ZFIN is now using GRCz12tu for Genomic Data
Gene
dhx30
- ID
- ZDB-GENE-130530-833
- Name
- DEAH (Asp-Glu-Ala-His) box helicase 30
- Symbol
- dhx30 Nomenclature History
- Previous Names
-
- zmp:0000000830 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA helicase activity; G-quadruplex RNA binding activity; and RNA helicase activity. Acts upstream of or within regulation of cellular response to heat; regulation of circadian sleep/wake cycle; and social behavior. Predicted to be located in mitochondrial nucleoid. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with variable motor and speech impairment. Orthologous to human DHX30 (DExH-box helicase 30).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Mannucci et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Mannucci et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neurodevelopmental disorder with variable motor and speech impairment | Alliance | Neurodevelopmental disorder with variable motor and speech impairment | 617804 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR002464 | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site |
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR007502 | Helicase-associated domain |
| Domain | IPR011545 | DEAD/DEAH-box helicase domain |
| Domain | IPR011709 | DEAD-box helicase, OB fold |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR014720 | Double-stranded RNA-binding domain |
| Domain | IPR056755 | dsRNA binding domain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Additional Resources | Length | DEAD-box helicase, OB fold | DEAD/DEAH-box helicase domain | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site | Double-stranded RNA-binding domain | dsRNA binding domain | Helicase-associated domain | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7FCG0 | InterPro | 1173 | |||||||||
| UniProtKB:A0A8M2BIG4 | InterPro | 1167 | |||||||||
| UniProtKB:A0A8N7TE51 | InterPro | 1173 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance