lrp6

ID

ZDB-GENE-090821-1

Name

low density lipoprotein receptor-related protein 6

Symbol

lrp6 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Ambiguous Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable Wnt receptor activity; Wnt-protein binding activity; and toxin transmembrane transporter activity. Predicted to be involved in nervous system development. Predicted to be located in early endosome; endoplasmic reticulum; and plasma membrane. Is expressed in posterior lateral line primordium. Human ortholog(s) of this gene implicated in disease of metabolism; myocardial infarction; and tooth agenesis. Orthologous to human LRP6 (LDL receptor related protein 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lrp6 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
coronary artery disease	Alliance	{Coronary artery disease, autosomal dominant, 2}	610947
		Exudative vitreoretinopathy 8	621268
		Osteopetrosis, autosomal dominant 4	621449
		Tooth agenesis, selective, 7	616724

Associated With lrp6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
Domain	IPR000742	EGF-like domain
Family	IPR017049	Low density lipoprotein receptor-related protein 5/6
Homologous_superfamily	IPR011042	Six-bladed beta-propeller, TolB-like
Homologous_superfamily	IPR036055	LDL receptor-like superfamily
Repeat	IPR000033	LDLR class B repeat
Repeat	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat