ZFIN is now using GRCz12tu for Genomic Data
Gene
lmod3
- ID
- ZDB-GENE-090313-353
- Name
- leiomodin 3 (fetal)
- Symbol
- lmod3 Nomenclature History
- Previous Names
-
- si:dkey-90a13.2
- si:dkey-90a13.7 (1)
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable actin binding activity and tropomyosin binding activity. Acts upstream of or within muscle contraction and skeletal muscle thin filament assembly. Predicted to be located in cytoplasm. Predicted to be active in M band and striated muscle thin filament. Used to study nemaline myopathy. Human ortholog(s) of this gene implicated in nemaline myopathy 10. Orthologous to human LMOD3 (leiomodin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Berger et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nemaline myopathy 10 | Alliance | Nemaline myopathy 10 | 616165 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| nemaline myopathy | AB + MO1-lmod3 + MO2-lmod3 | standard conditions | Yuen et al., 2014 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Leucine-rich repeat domain superfamily | Tropomodulin |
|---|---|---|---|---|
| UniProtKB:A0A2R8QDE5 | InterPro | 670 | ||
| UniProtKB:A0A8M9QA08 | InterPro | 670 | ||
| UniProtKB:E7F7X0 | InterPro | 670 | ||
| UniProtKB:A0ACD6B7W5 | InterPro | 670 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-lmod3 | polyclonal | IgG | Rabbit |
|
Proteintech
|
2 |
Plasmids
No data available
- Genome Browsers