ZFIN is now using GRCz12tu for Genomic Data
Gene
ern2
- ID
- ZDB-GENE-090312-15
- Name
- endoplasmic reticulum to nucleus signaling 2
- Symbol
- ern2 Nomenclature History
- Previous Names
-
- si:ch211-14k19.11
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable several functions, including ATP binding activity; protein homodimerization activity; and protein kinase activity. Predicted to be involved in several processes, including IRE1-mediated unfolded protein response; positive regulation of JNK cascade; and positive regulation of RNA splicing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of protein-containing complex. Is expressed in liver and male organism. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to several human genes including ERN2 (endoplasmic reticulum to nucleus signaling 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR010513 | KEN domain |
| Family | IPR045133 | Serine/threonine-protein kinase/endoribonuclease IRE1/2-like |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011047 | Quinoprotein alcohol dehydrogenase-like superfamily |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR038357 | KEN domain superfamily |
| Repeat | IPR018391 | Pyrrolo-quinoline quinone beta-propeller repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | KEN domain | KEN domain superfamily | Protein kinase domain | Protein kinase-like domain superfamily | Pyrrolo-quinoline quinone beta-propeller repeat | Quinoprotein alcohol dehydrogenase-like superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinase/endoribonuclease IRE1/2-like | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B496 | InterPro | 776 | |||||||||
| UniProtKB:A0A8M9Q0A4 | InterPro | 777 | |||||||||
| UniProtKB:A0A8M1QQI8 | InterPro | 930 | |||||||||
| UniProtKB:A0A8M9PPK0 | InterPro | 931 | |||||||||
| UniProtKB:A0AC58JG39 | InterPro | 731 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers