ZFIN is now using GRCz12tu for Genomic Data
Gene
fbln2
- ID
- ZDB-GENE-060711-1
- Name
- fibulin 2
- Symbol
- fbln2 Nomenclature History
- Previous Names
-
- im:6907068
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within positive regulation of BMP signaling pathway and regulation of chondrocyte differentiation. Predicted to be located in extracellular region. Predicted to be non-collagenous component of basement membrane. Is expressed in several structures, including cardiovascular system; head; hypochord; mesoderm; and tail bud. Orthologous to human FBLN2 (fibulin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6907068 (21 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Niu et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000020 | Anaphylatoxin/fibulin |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR026823 | Complement Clr-like EGF domain |
| Domain | IPR049883 | NOTCH1, EGF-like calcium-binding domain |
| Domain | IPR055088 | Fibulin, C-terminal Ig-like domain |
| Domain | IPR056612 | Fibulin-2 domain |
| Family | IPR050751 | Extracellular matrix structural protein |
| Family | IPR052080 | von Willebrand factor C/EGF & Fibrillin |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Additional Resources | Length | Anaphylatoxin/fibulin | Complement Clr-like EGF domain | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Extracellular matrix structural protein | Fibulin-2 domain | Fibulin, C-terminal Ig-like domain | Growth factor receptor cysteine-rich domain superfamily | NOTCH1, EGF-like calcium-binding domain | von Willebrand factor C/EGF & Fibrillin |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1RCR3 | InterPro | 1408 | ||||||||||||
| UniProtKB:A0A8M2BH82 | InterPro | 1361 | ||||||||||||
| UniProtKB:A0ACD6B6M0 | InterPro | 1408 | ||||||||||||
| UniProtKB:A0AC58GT12 | InterPro | 1408 | ||||||||||||
| UniProtKB:A0AC58GT16 | InterPro | 1361 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers