ZFIN is now using GRCz12tu for Genomic Data
Gene
usp22
- ID
- ZDB-GENE-060512-211
- Name
- ubiquitin specific peptidase 22
- Symbol
- usp22 Nomenclature History
- Previous Names
-
- zgc:136342
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 105. Orthologous to several human genes including USP22 (ubiquitin specific peptidase 22).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Tse et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018200 | Ubiquitin specific protease, conserved site |
| Domain | IPR001394 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
| Domain | IPR001607 | Zinc finger, UBP-type |
| Domain | IPR028889 | Ubiquitin specific protease UPS, catalytic domain |
| Family | IPR050185 | Ubiquitin carboxyl-terminal hydrolase |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Papain-like cysteine peptidase superfamily | Peptidase C19, ubiquitin carboxyl-terminal hydrolase | Ubiquitin carboxyl-terminal hydrolase | Ubiquitin specific protease, conserved site | Ubiquitin specific protease UPS, catalytic domain | Zinc finger, RING/FYVE/PHD-type | Zinc finger, UBP-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QEE8 | InterPro | 507 | |||||||
| UniProtKB:A0A8M9QMM5 | InterPro | 506 | |||||||
| UniProtKB:A6H8I0 | InterPro | 506 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers