ZFIN is now using GRCz12tu for Genomic Data
Gene
grhl2b
- ID
- ZDB-GENE-060503-719
- Name
- grainyhead-like transcription factor 2b
- Symbol
- grhl2b Nomenclature History
- Previous Names
-
- grhl2
- si:dkey-21k18.2
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables transcription cis-regulatory region binding activity. Acts upstream of or within apoptotic process involved in morphogenesis; inner ear development; and midbrain-hindbrain boundary morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including anterior axial hypoblast; midbrain hindbrain boundary neural rod; neurogenic placode; optic vesicle; and posterior lateral line system. Used to study autosomal dominant nonsyndromic deafness. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28; ectodermal dysplasia; and posterior polymorphous corneal dystrophy 4. Orthologous to human GRHL2 (grainyhead like transcription factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 28 | Alliance | Deafness, autosomal dominant 28 | 608641 |
| posterior polymorphous corneal dystrophy 4 | Alliance | Corneal dystrophy, posterior polymorphous, 4 | 618031 |
| Ectodermal dysplasia/short stature syndrome | 616029 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness | grhl2btsu086Gt/tsu086Gt (AB) | standard conditions | Han et al., 2011 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CP2 transcription factor | GRHL1/CP2, C-terminal domain | Transcription factor CP2-like |
|---|---|---|---|---|---|
| UniProtKB:F7VJQ5 | InterPro | 601 | |||
| UniProtKB:A0A2R8QAV0 | InterPro | 554 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
grhl2b-201
(1)
|
Ensembl | 3,699 nt | ||
| mRNA |
grhl2b-202
(1)
|
Ensembl | 1,786 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers