plch1

ID

ZDB-GENE-060503-398

Name

phospholipase C, eta 1

Symbol

plch1 Nomenclature History

Previous Names

si:ch211-203b20.8

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable calcium ion binding activity and phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Predicted to be involved in intracellular signal transduction; lipid catabolic process; and phosphatidylinositol metabolic process. Predicted to be located in cytoplasm and plasma membrane. Is expressed in brain and liver. Human ortholog(s) of this gene implicated in holoprosencephaly. Orthologous to human PLCH1 (phospholipase C eta 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Jelen et al., 2007

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With plch1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Holoprosencephaly 14	619895

Associated With plch1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

No data available

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9PMN2	InterPro	1753
UniProtKB:A0A8M6Z2T4	InterPro	980
UniProtKB:A0A8M9PFX4	InterPro	1765
UniProtKB:A0A8M9PPN9	InterPro	1735
UniProtKB:A0A8M9P1F6	InterPro	1795
UniProtKB:A0A8M9PVZ6	InterPro	1715
UniProtKB:A0A8M9PAI3	InterPro	1775
UniProtKB:A0A8M6YTQ9	InterPro	979
UniProtKB:A0AB32T7K1	InterPro	1795
UniProtKB:A0AB32TNM1	InterPro	1715
UniProtKB:A0AC58HVR4	InterPro	1587
UniProtKB:A0AC58HVR7	InterPro	852
UniProtKB:A0AC58HVS4	InterPro	832
UniProtKB:A0AC58HVT4	InterPro	851
UniProtKB:A0AC58HVX4	InterPro	1795