ZFIN is now using GRCz12tu for Genomic Data
Gene
cacna1ia
- ID
- ZDB-GENE-060503-324
- Name
- calcium voltage-gated channel subunit alpha1 Ia
- Symbol
- cacna1ia Nomenclature History
- Previous Names
-
- cacna1i
- si:ch211-51h13.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable voltage-gated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated calcium channel complex. Is expressed in atrium and cardiac ventricle. Human ortholog(s) of this gene implicated in language disorder and schizophrenia. Orthologous to human CACNA1I (calcium voltage-gated channel subunit alpha1 I).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with speech impairment and with or without seizures | 620114 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ion transport domain | Voltage-dependent calcium channel, T-type, alpha-1 subunit | Voltage-dependent channel domain superfamily | Voltage-gated cation channel calcium and sodium |
|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8Q1A5 | InterPro | 2122 | ||||
| UniProtKB:A0A8M9PEP7 | InterPro | 2121 | ||||
| UniProtKB:A0AB40E752 | InterPro | 2191 | ||||
| UniProtKB:A0AC58J2B4 | InterPro | 2145 | ||||
| UniProtKB:A0AC58J2C0 | InterPro | 2191 | ||||
| UniProtKB:A0AC58J2C2 | InterPro | 2190 | ||||
| UniProtKB:A0AC58J2D3 | InterPro | 2191 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cacna1i-202
(1)
|
Ensembl | 7,247 nt | ||
| mRNA |
cacna1ia-201
(1)
|
Ensembl | 7,010 nt | ||
| mRNA |
cacna1ia-203
(1)
|
Ensembl | 7,148 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers