ZFIN is now using GRCz12tu for Genomic Data
Gene
zgc:136872
- ID
- ZDB-GENE-060421-5204
- Name
- zgc:136872
- Symbol
- zgc:136872 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable calcium ion binding activity and calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in eosinophilic esophagitis. Orthologous to several human genes including CAPN14 (calpain 14).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Ma et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
| Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
| Domain | IPR001300 | Peptidase C2, calpain, catalytic domain |
| Domain | IPR002048 | EF-hand domain |
| Domain | IPR022682 | Peptidase C2, calpain, large subunit, domain III |
| Domain | IPR022683 | Peptidase C2, calpain, domain III |
| Domain | IPR033883 | Calpain subdomain III |
| Domain | IPR054069 | Calpain-3/13-like, C-terminal EF-hand |
| Family | IPR022684 | Peptidase C2, calpain family |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR036213 | Calpain large subunit, domain III superfamily |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Calpain-3/13-like, C-terminal EF-hand | Calpain large subunit, domain III superfamily | Calpain subdomain III | Cysteine peptidase, cysteine active site | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Papain-like cysteine peptidase superfamily | Peptidase C2, calpain, catalytic domain | Peptidase C2, calpain, domain III | Peptidase C2, calpain family | Peptidase C2, calpain, large subunit, domain III |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QW40 | InterPro | 693 | ||||||||||||
| UniProtKB:Q1RLS9 | InterPro | 693 | ||||||||||||
| UniProtKB:A0AC58HNJ4 | InterPro | 693 | ||||||||||||
| UniProtKB:A0AC58HNN2 | InterPro | 693 | ||||||||||||
| UniProtKB:A0AC58HNN5 | InterPro | 689 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
zgc:136872-201
(1)
|
Ensembl | 2,460 nt | ||
| mRNA |
zgc:136872-202
(1)
|
Ensembl | 2,545 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers