ZFIN is now using GRCz12tu for Genomic Data
Gene
ctbp1
- ID
- ZDB-GENE-060421-4235
- Name
- C-terminal binding protein 1
- Symbol
- ctbp1 Nomenclature History
- Previous Names
-
- fa96d06
- wu:fa96d06
- zgc:136929
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable several functions, including transcription coactivator activity; transcription coregulator binding activity; and transcription corepressor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in tooth disease. Orthologous to human CTBP1 (C-terminal binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome | 617915 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR029752 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 |
| Conserved_site | IPR029753 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site |
| Domain | IPR006139 | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain |
| Domain | IPR006140 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain |
| Family | IPR043322 | C-terminal binding protein |
| Family | IPR051638 | C-terminal-binding dehydrogenase |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | C-terminal-binding dehydrogenase | C-terminal binding protein | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1RLQ4 | InterPro | 440 | |||||||
| UniProtKB:A0A2R8QPP7 | InterPro | 429 | |||||||
| UniProtKB:A0AC58H6S8 | InterPro | 440 | |||||||
| UniProtKB:A0AC58H6T2 | InterPro | 440 | |||||||
| UniProtKB:A0AC58H6T3 | InterPro | 440 | |||||||
| UniProtKB:A0AC58H6T4 | InterPro | 440 | |||||||
| UniProtKB:A0AC58H6T5 | InterPro | 421 | |||||||
| UniProtKB:A0AC58H6T6 | InterPro | 440 | |||||||
| UniProtKB:A0AC58H6T8 | InterPro | 440 | |||||||
| UniProtKB:A0AC58H6U4 | InterPro | 440 | |||||||
| UniProtKB:A0AC58H6U8 | InterPro | 421 | |||||||
| UniProtKB:A0AC58H6X2 | InterPro | 421 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ctbp1-203
(1)
|
Ensembl | 2,024 nt | ||
| mRNA |
ctbp1-204
(1)
|
Ensembl | 2,131 nt | ||
| mRNA |
zgc:136929-201
(1)
|
Ensembl | 2,907 nt | ||
| mRNA |
zgc:136929-202
(1)
|
Ensembl | 1,374 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance