ZFIN is now using GRCz12tu for Genomic Data
Gene
lyset
- ID
- ZDB-GENE-041001-121
- Name
- lysosomal enzyme trafficking factor
- Symbol
- lyset Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to be involved in lysosome organization and regulation of vesicle-mediated transport. Predicted to be located in Golgi membrane. Used to study mucolipidosis. Human ortholog(s) of this gene implicated in inherited metabolic disorder. Orthologous to human LYSET (lysosomal enzyme trafficking factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7146490 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Zhang et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Dysostosis multiplex, Ain-Naz type | 619345 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| mucolipidosis | WT + CRISPR1-lyset + CRISPR2-lyset + CRISPR3-lyset + CRISPR4-lyset | standard conditions | Zhang et al., 2022 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR028024 | Lysosomal enzyme trafficking factor |
Domain Details Per Protein
| Protein | Additional Resources | Length | Lysosomal enzyme trafficking factor |
|---|---|---|---|
| UniProtKB:Q5TZA3 | InterPro | 142 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tmem251-201
(1)
|
Ensembl | 1,949 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers