ZFIN is now using GRCz12tu for Genomic Data
Gene
flad1
- ID
- ZDB-GENE-040822-44
- Name
- flavin adenine dinucleotide synthetase 1
- Symbol
- flad1 Nomenclature History
- Previous Names
-
- fa92c06
- wu:fa92c06
- zgc:91843
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable FAD diphosphatase activity; FMN adenylyltransferase activity; and NADH pyrophosphatase activity. Predicted to be involved in FAD biosynthetic process. Predicted to be located in mitochondrial matrix and nucleus. Human ortholog(s) of this gene implicated in muscular dystrophy. Orthologous to human FLAD1 (flavin adenine dinucleotide synthetase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91843 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Lipid storage myopathy due to flavin adenine dinucleotide synthetase deficiency | 255100 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001453 | MoaB/Mog domain |
| Domain | IPR002500 | Phosphoadenosine phosphosulphate reductase domain |
| Domain | IPR006612 | THAP-type zinc finger |
| Domain | IPR056596 | FAD synthase, middle domain |
| Family | IPR012183 | Bifunctional FAD diphosphatase/FAD synthase |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
| Homologous_superfamily | IPR036425 | MoaB/Mog-like domain superfamily |
| Homologous_superfamily | IPR038441 | THAP-type zinc finger superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Bifunctional FAD diphosphatase/FAD synthase | FAD synthase, middle domain | MoaB/Mog domain | MoaB/Mog-like domain superfamily | Phosphoadenosine phosphosulphate reductase domain | Rossmann-like alpha/beta/alpha sandwich fold | THAP-type zinc finger | THAP-type zinc finger superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BH00 | InterPro | 521 | ||||||||
| UniProtKB:Q68EH8 | InterPro | 497 | ||||||||
| UniProtKB:A0A0R4INK4 | InterPro | 614 | ||||||||
| UniProtKB:A0AC58HG90 | InterPro | 521 | ||||||||
| UniProtKB:A0AC58HG93 | InterPro | 521 | ||||||||
| UniProtKB:A0AC58HGA4 | InterPro | 633 | ||||||||
| UniProtKB:A0AC58HGA8 | InterPro | 497 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers