ZFIN is now using GRCz12tu for Genomic Data
Gene
cacna1db
- ID
- ZDB-GENE-040525-3
- Name
- calcium voltage-gated channel subunit alpha1 Db
- Symbol
- cacna1db Nomenclature History
- Previous Names
-
- cav1.3b (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cytoskeletal protein binding activity and voltage-gated calcium channel activity involved in cardiac muscle cell action potential. Predicted to be involved in several processes, including calcium ion transmembrane import into cytosol; membrane depolarization during cardiac muscle cell action potential; and regulation of metal ion transport. Predicted to be located in sarcolemma. Predicted to be part of voltage-gated calcium channel complex. Is expressed in atrium and cardiac ventricle. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus and visual epilepsy. Orthologous to human CACNA1D (calcium voltage-gated channel subunit alpha1 D).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Liu et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| congenital heart disease | AB + MO1-cacna1db | standard conditions | Liu et al., 2022 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:A0A8M9QJ57 | InterPro | 2087 |
| UniProtKB:A0AC58GCB9 | InterPro | 2086 |
| UniProtKB:A0AC58GCC0 | InterPro | 2060 |
| UniProtKB:A0AC58GCC9 | InterPro | 2061 |
| UniProtKB:A0AC58GCD0 | InterPro | 2061 |
| UniProtKB:A0AC58GCD1 | InterPro | 2059 |
| UniProtKB:A0AC58GCD2 | InterPro | 2078 |
| UniProtKB:A0AC58GCD4 | InterPro | 2052 |
| UniProtKB:A0AC58GCD6 | InterPro | 2060 |
| UniProtKB:A0AC58GCD8 | InterPro | 2051 |
| UniProtKB:A0AC58GCD9 | InterPro | 2034 |
| UniProtKB:A0AC58GCE0 | InterPro | 2035 |
| UniProtKB:A0AC58GCE1 | InterPro | 2033 |
| UniProtKB:A0AC58GCE2 | InterPro | 2050 |
| UniProtKB:A0AC58GCE4 | InterPro | 2024 |
| UniProtKB:A0AC58GCE5 | InterPro | 2087 |
| UniProtKB:A0AC58GCE6 | InterPro | 2025 |
| UniProtKB:A0AC58GCE8 | InterPro | 2026 |
| UniProtKB:A0AC58GCE9 | InterPro | 2052 |
| UniProtKB:A0AC58GCF0 | InterPro | 2023 |
| UniProtKB:A0AC58GCF1 | InterPro | 1980 |
| UniProtKB:A0AC58GCF3 | InterPro | 2023 |
| UniProtKB:A0AC58GCF4 | InterPro | 2008 |
| UniProtKB:A0AC58GCF8 | InterPro | 2033 |
| UniProtKB:A0AC58GCF9 | InterPro | 1146 |
| UniProtKB:A0AC58GCG5 | InterPro | 1997 |
| UniProtKB:A0AC58GCG8 | InterPro | 1998 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cacna1db-205
(1)
|
Ensembl | 802 nt |
Interactions and Pathways
No data available
Plasmids
- Genome Browsers