ZFIN is now using GRCz12tu for Genomic Data
Gene
fbxw11b
- ID
- ZDB-GENE-040426-2903
- Name
- F-box and WD repeat domain containing 11b
- Symbol
- fbxw11b Nomenclature History
- Previous Names
-
- btrc2
- fbxw11
- wu:fa12e12
- wu:fb11f03
- zgc:63728
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in brain; head mesenchyme; oral epithelium; pectoral fin; and retina. Orthologous to human FBXW11 (F-box and WD repeat domain containing 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63728 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental, jaw, eye, and digital syndrome | 618914 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR001810 | F-box domain |
| Domain | IPR021977 | D domain of beta-TrCP |
| Family | IPR050995 | WD repeat and F-box domain-containing protein |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036047 | F-box-like domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
| Repeat | IPR020472 | G-protein beta WD-40 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | D domain of beta-TrCP | F-box domain | F-box-like domain superfamily | G-protein beta WD-40 repeat | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily | WD repeat and F-box domain-containing protein |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E9QCK5 | InterPro | 524 | |||||||||
| UniProtKB:A0A2R8RWN9 | InterPro | 534 | |||||||||
| UniProtKB:F6PB05 | InterPro | 531 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fbxw11b-201
(1)
|
Ensembl | 2,503 nt | ||
| mRNA |
fbxw11b-202
(1)
|
Ensembl | 2,496 nt | ||
| mRNA |
fbxw11b-204
(1)
|
Ensembl | 2,502 nt | ||
| ncRNA |
fbxw11b-002
(1)
|
Ensembl | 765 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers