ZFIN is now using GRCz12tu for Genomic Data
Gene
usp25
- ID
- ZDB-GENE-040426-2847
- Name
- ubiquitin specific peptidase 25
- Symbol
- usp25 Nomenclature History
- Previous Names
-
- wu:fi33c05
- wu:fo67e06
- wu:fp97a04
- zgc:55791
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cysteine-type deubiquitinase activity. Acts upstream of or within cranial skeletal system development and dorsal/ventral pattern formation. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in generalized epilepsy. Orthologous to human USP25 (ubiquitin specific peptidase 25).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55791 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Epilepsy, idiopathic generalized, susceptibility to, 19} | 621064 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003903 | Ubiquitin interacting motif |
| Conserved_site | IPR018200 | Ubiquitin specific protease, conserved site |
| Conserved_site | IPR054108 | Ubiquitin carboxyl-terminal hydrolase 25/28, UIM |
| Domain | IPR001394 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
| Domain | IPR028889 | Ubiquitin specific protease UPS, catalytic domain |
| Domain | IPR054109 | UBA-like domain |
| Family | IPR050164 | Ubiquitin carboxyl-terminal hydrolases |
| Homologous_superfamily | IPR009060 | UBA-like superfamily |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
- Genome Browsers