ZFIN is now using GRCz12tu for Genomic Data
Gene
got1
- ID
- ZDB-GENE-040426-2003
- Name
- glutamic-oxaloacetic transaminase 1, soluble
- Symbol
- got1 Nomenclature History
- Previous Names
-
- wu:fj63b09
- zgc:55996
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable L-aspartate:2-oxoglutarate transaminase activity. Predicted to be involved in L-aspartate biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in retina. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to human GOT1 (glutamic-oxaloacetic transaminase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Aspartate aminotransferase, serum level of, QTL1 | 614419 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR004838 | Aminotransferases, class-I, pyridoxal-phosphate-binding site |
| Domain | IPR004839 | Aminotransferase, class I/classII, large domain |
| Family | IPR000796 | Aspartate/other aminotransferase |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
Domain Details Per Protein
| Protein | Additional Resources | Length | Aminotransferase, class I/classII, large domain | Aminotransferases, class-I, pyridoxal-phosphate-binding site | Aspartate/other aminotransferase | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZUW8 | InterPro | 410 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers