fbxo43

ID

ZDB-GENE-040426-1645

Name

F-box protein 43

Symbol

fbxo43 Nomenclature History

Previous Names

zgc:66488

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable ubiquitin ligase inhibitor activity. Predicted to be involved in G1/S transition of mitotic cell cycle; negative regulation of meiotic nuclear division; and regulation of mitotic nuclear division. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in spermatogenic failure 64. Orthologous to human FBXO43 (F-box protein 43).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:113982 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fbxo43 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spermatogenic failure 64	Alliance	Spermatogenic failure 64	619696
		Oocyte/zygote/embryo maturation arrest 12	619697

Associated With fbxo43 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR044064	Zinc finger ZBR-type domain
Family	IPR047147	F-box only protein 5/43

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:Q7SYI4	InterPro	557
UniProtKB:F1QE49	InterPro	557
UniProtKB:A0A8M9PJC1	InterPro	505
UniProtKB:A0AC58HFR4	InterPro	557
UniProtKB:A0AC58HFR8	InterPro	505
UniProtKB:A0AC58HFT3	InterPro	505
UniProtKB:A0AC58HFT7	InterPro	505