ZFIN is now using GRCz12tu for Genomic Data
Gene
arl6ip1
- ID
- ZDB-GENE-040426-1087
- Name
- ARL6 interacting reticulophagy regulator 1
- Symbol
- arl6ip1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Acts upstream of or within neural crest cell migration and retina morphogenesis in camera-type eye. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane and endoplasmic reticulum tubular network. Is expressed in several structures, including blastodisc; central nervous system; hypochord; optic cup; and retina. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 61. Orthologous to human ARL6IP1 (ARL6 interacting reticulophagy regulator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7140611 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 20 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary spastic paraplegia 61 | Alliance | Spastic paraplegia 61, autosomal recessive | 615685 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ER-associated autophagy and membrane dynamics regulator | RETREG1-3/ARL6IP-like, N-terminal reticulon-homology domain |
|---|---|---|---|---|
| UniProtKB:Q7ZWB4 | InterPro | 203 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arl6ip1-201
(1)
|
Ensembl | 1,590 nt | ||
| mRNA |
arl6ip1-202
(1)
|
Ensembl | 615 nt | ||
| ncRNA |
arl6ip1-003
(1)
|
Ensembl | 781 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-arl6ip1 | polyclonal | IgG | Rabbit |
|
Abcam plc
|
4 |
Plasmids
No data available
- Genome Browsers