ZFIN is now using GRCz12tu for Genomic Data
Gene
prdx3
- ID
- ZDB-GENE-030826-18
- Name
- peroxiredoxin 3
- Symbol
- prdx3 Nomenclature History
- Previous Names
-
- cb718 (1)
- wu:fk49e09
- zgc:110282
- zgc:112512
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable thioredoxin-dependent peroxiredoxin activity. Predicted to be involved in cell redox homeostasis; hydrogen peroxide catabolic process; and response to oxidative stress. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; eye; midbrain; and musculature system. Used to study autosomal recessive spinocerebellar ataxia 32. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 32 and corneal endothelial dystrophy. Orthologous to human PRDX3 (peroxiredoxin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb718 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Naef et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive spinocerebellar ataxia 32 | Alliance | Spinocerebellar ataxia, autosomal recessive 32 | 619862 |
| Corneal dystrophy, punctiform and polychromatic pre-Descemet | 619871 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autosomal recessive spinocerebellar ataxia 32 | AB + CRISPR5-prdx3 | standard conditions | Naef et al., 2024 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000866 | Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant |
| Domain | IPR013766 | Thioredoxin domain |
| Domain | IPR019479 | Peroxiredoxin, C-terminal |
| Family | IPR050217 | Thiol-specific antioxidant peroxiredoxin |
| Homologous_superfamily | IPR036249 | Thioredoxin-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant | Peroxiredoxin, C-terminal | Thiol-specific antioxidant peroxiredoxin | Thioredoxin domain | Thioredoxin-like superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q5BJB9 | InterPro | 250 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers