ZFIN is now using GRCz12tu for Genomic Data
Gene
f13a1b
- ID
- ZDB-GENE-030131-9634
- Name
- coagulation factor XIII, A1 polypeptide b
- Symbol
- f13a1b Nomenclature History
- Previous Names
-
- f13a1
- fo83d04
- FX111a-87 (1)
- wu:fo83d04
- zgc:153334
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in blood coagulation, fibrin clot formation. Is expressed in pectoral fin and retina. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); factor XIII deficiency; priapism; and thrombophilia (multiple). Orthologous to human F13A1 (coagulation factor XIII A chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| factor XIII deficiency | Alliance | Factor XIIIA deficiency | 613225 |
| thrombophilia due to thrombin defect | Alliance | {Venous thrombosis, protection against} | 188050 |
| {Myocardial infarction, protection against} | 608446 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001102 | Transglutaminase, N-terminal |
| Domain | IPR002931 | Transglutaminase-like |
| Domain | IPR008958 | Transglutaminase, C-terminal |
| Family | IPR023608 | Protein-glutamine gamma-glutamyltransferase, animal |
| Family | IPR050779 | Protein-glutamine gamma-glutamyltransferases |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
| Homologous_superfamily | IPR036238 | Transglutaminase, C-terminal domain superfamily |
| Homologous_superfamily | IPR036985 | Transglutaminase-like superfamily |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin E-set | Immunoglobulin-like fold | Papain-like cysteine peptidase superfamily | Protein-glutamine gamma-glutamyltransferase, animal | Protein-glutamine gamma-glutamyltransferases | Transglutaminase, C-terminal | Transglutaminase, C-terminal domain superfamily | Transglutaminase-like | Transglutaminase-like superfamily | Transglutaminase, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QC25 | InterPro | 742 | ||||||||||
| UniProtKB:Q08CA3 | InterPro | 742 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
f13a1b-201
(1)
|
Ensembl | 5,899 nt | ||
| mRNA |
f13a1b-202
(1)
|
Ensembl | 3,162 nt | ||
| mRNA |
f13a1b-203
(1)
|
Ensembl | 2,233 nt | ||
| mRNA |
f13a1b-204
(1)
|
Ensembl | 2,568 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers