ZFIN is now using GRCz12tu for Genomic Data
Gene
habp2
- ID
- ZDB-GENE-030131-4721
- Name
- hyaluronan binding protein 2
- Symbol
- habp2 Nomenclature History
- Previous Names
-
- fd56a04
- wu:fd56a04 (1)
- zgc:171352
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular region. Is expressed in liver. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma; thrombophilia due to thrombin defect; and thrombosis. Orthologous to human HABP2 (hyaluronan binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| thrombophilia due to thrombin defect | Alliance | {Venous thromboembolism, susceptibility to} | 188050 |
| {?Thyroid cancer, nonmedullary, 5} | 616535 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018114 | Serine proteases, trypsin family, histidine active site |
| Active_site | IPR033116 | Serine proteases, trypsin family, serine active site |
| Conserved_site | IPR018056 | Kringle, conserved site |
| Domain | IPR000001 | Kringle |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001254 | Serine proteases, trypsin domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Family | IPR001314 | Peptidase S1A, chymotrypsin family |
| Family | IPR012224 | Peptidase S1A, coagulation factor VII/IX/X/C/Z |
| Family | IPR050127 | Serine Proteases (Peptidase S1 Family) |
| Homologous_superfamily | IPR009003 | Peptidase S1, PA clan |
| Homologous_superfamily | IPR013806 | Kringle-like fold |
| Homologous_superfamily | IPR038178 | Kringle superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like calcium-binding domain | EGF-like domain | Kringle | Kringle, conserved site | Kringle-like fold | Kringle superfamily | Peptidase S1A, chymotrypsin family | Peptidase S1A, coagulation factor VII/IX/X/C/Z | Peptidase S1, PA clan | Serine Proteases (Peptidase S1 Family) | Serine proteases, trypsin domain | Serine proteases, trypsin family, histidine active site | Serine proteases, trypsin family, serine active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QW52 | InterPro | 546 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers