ZFIN is now using GRCz12tu for Genomic Data
Gene
chrng
- ID
- ZDB-GENE-030131-3805
- Name
- cholinergic receptor, nicotinic, gamma
- Symbol
- chrng Nomenclature History
- Previous Names
-
- chrngl
- AChr gamma (1)
- wu:fc54e06
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Contributes to acetylcholine receptor activity. Acts upstream of or within cellular response to acetylcholine and cholinergic synaptic transmission. Part of acetylcholine-gated channel complex. Is expressed in musculature system. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita and contractures, pterygia, and spondylocarpotarsal fusion syndrome. Orthologous to human CHRNG (cholinergic receptor nicotinic gamma subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| contractures, pterygia, and spondylocarpotarsal fusion syndrome | Alliance | Escobar syndrome | 265000 |
| contractures, pterygia, and spondylocarpotarsal fusion syndrome | Alliance | Multiple pterygium syndrome, lethal type | 253290 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018000 | Neurotransmitter-gated ion-channel, conserved site |
| Domain | IPR006029 | Neurotransmitter-gated ion-channel transmembrane domain |
| Domain | IPR006202 | Neurotransmitter-gated ion-channel ligand-binding domain |
| Family | IPR002394 | Nicotinic acetylcholine receptor |
| Family | IPR006201 | Neurotransmitter-gated ion-channel |
| Homologous_superfamily | IPR036719 | Neurotransmitter-gated ion-channel transmembrane domain superfamily |
| Homologous_superfamily | IPR036734 | Neurotransmitter-gated ion-channel ligand-binding domain superfamily |
| Homologous_superfamily | IPR038050 | Neuronal acetylcholine receptor |
Domain Details Per Protein
| Protein | Additional Resources | Length | Neuronal acetylcholine receptor | Neurotransmitter-gated ion-channel | Neurotransmitter-gated ion-channel, conserved site | Neurotransmitter-gated ion-channel ligand-binding domain | Neurotransmitter-gated ion-channel ligand-binding domain superfamily | Neurotransmitter-gated ion-channel transmembrane domain | Neurotransmitter-gated ion-channel transmembrane domain superfamily | Nicotinic acetylcholine receptor |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:G1FMP9 | InterPro | 540 | ||||||||
| UniProtKB:E7F9V1 | InterPro | 540 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-chrne,chrng | polyclonal | Rabbit |
|
1 |
Plasmids
No data available
- Genome Browsers