ZFIN is now using GRCz12tu for Genomic Data

Gene

chsy1

ID

ZDB-GENE-030131-3127

Name

chondroitin sulfate synthase 1

Symbol

chsy1 Nomenclature History

Previous Names

chys1
wu:fc27h05
wu:fc27h06
zgc:64191

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Acts upstream of or within several processes, including animal organ morphogenesis; chondroitin sulfate proteoglycan biosynthetic process; and pectoral fin development. Predicted to be located in Golgi cisterna membrane and Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including central nervous system; cranium; inner ear; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in temtamy preaxial brachydactyly syndrome. Orthologous to human CHSY1 (chondroitin sulfate synthase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:64191 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With chsy1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
temtamy preaxial brachydactyly syndrome	Alliance	Temtamy preaxial brachydactyly syndrome	605282

Associated With chsy1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR008428	Chondroitin N-acetylgalactosaminyltransferase
Family	IPR051227	Chondroitin sulfate glycosyltransferase
Homologous_superfamily	IPR029044	Nucleotide-diphospho-sugar transferases

Domain Details Per Protein

Protein	Additional Resources	Length	Chondroitin N-acetylgalactosaminyltransferase	Chondroitin sulfate glycosyltransferase	Nucleotide-diphospho-sugar transferases
UniProtKB:Q6P296	InterPro	801
UniProtKB:A0AC58FXN4	InterPro	653

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	chsy1-201 (1) Ensembl	Ensembl		3,921 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations