ZFIN is now using GRCz12tu for Genomic Data
Gene
mtmr14
- ID
- ZDB-GENE-030131-2649
- Name
- myotubularin related protein 14
- Symbol
- mtmr14 Nomenclature History
- Previous Names
-
- fc14d11
- wu:fc14d11 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity and phosphatidylinositol-3-phosphate phosphatase activity. Acts upstream of or within several processes, including muscle cell cellular homeostasis; musculoskeletal movement; and regulation of autophagy. Predicted to be active in perinuclear region of cytoplasm. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in centronuclear myopathy 1. Orthologous to human MTMR14 (myotubularin related protein 14).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Diotel et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Dowling et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| centronuclear myopathy 1 | Alliance | {Centronuclear myopathy, autosomal, modifier of} | 160150 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | MTMR14, PH-GRAM domain | Myotubularin-related protein 14 | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase-like |
|---|---|---|---|---|---|---|
| UniProtKB:E7F0C5 | InterPro | 630 | ||||
| UniProtKB:A0A8M3ATB6 | InterPro | 611 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mtmr14-201
(1)
|
Ensembl | 5,230 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers