ZFIN is now using GRCz12tu for Genomic Data
Gene
slit3
- ID
- ZDB-GENE-010306-4
- Name
- slit homolog 3 (Drosophila)
- Symbol
- slit3 Nomenclature History
- Previous Names
-
- zgc:111911
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable Roundabout binding activity and heparin binding activity. Predicted to be involved in axon guidance and negative chemotaxis. Is expressed in several structures, including axial mesoderm; fin; nervous system; pectoral fin bud; and presumptive mesoderm. Orthologous to human SLIT3 (slit guidance ligand 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu898 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000372 | Leucine-rich repeat N-terminal domain |
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001791 | Laminin G domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR006207 | Cystine knot, C-terminal |
| Family | IPR051355 | Notch and Slit guidance protein |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | Cysteine-rich flanking region, C-terminal | Cystine knot, C-terminal | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Laminin G domain | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat N-terminal domain | Leucine-rich repeat, typical subtype | Notch and Slit guidance protein |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3ARY3 | InterPro | 1322 | |||||||||||||||
| UniProtKB:F1RCV3 | InterPro | 1516 | |||||||||||||||
| UniProtKB:A0AC58H752 | InterPro | 1526 | |||||||||||||||
| UniProtKB:A0AC58H753 | InterPro | 1322 | |||||||||||||||
| UniProtKB:A0AC58H763 | InterPro | 1332 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
- Genome Browsers