runx1

ID

ZDB-GENE-000605-1

Name

RUNX family transcription factor 1

Symbol

runx1 Nomenclature History

Previous Names

runx1a (1)
runxa
aml1 (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cardiac muscle tissue regeneration; positive regulation of collagen biosynthetic process; and positive regulation of extracellular matrix organization. Acts upstream of or within several processes, including endothelial to hematopoietic transition; hemopoiesis; and regulation of gene expression. Predicted to be located in cytosol. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including cranial ganglion; hematopoietic cell; hematopoietic system; mesoderm; and vasculature. Human ortholog(s) of this gene implicated in acute myeloid leukemia and esophagus squamous cell carcinoma. Orthologous to human RUNX1 (RUNX family transcription factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

421 figures from 205 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 39 figures from 23 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With runx1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute myeloid leukemia	Alliance	Leukemia, acute myeloid	601626
		Platelet disorder, familial, with associated myeloid malignancy	601399

Associated With runx1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013524	Runt domain
Domain	IPR013711	Runx, C-terminal domain
Family	IPR000040	Acute myeloid leukemia 1 protein (AML1)/Runt
Family	IPR016554	Runt-related transcription factor RUNX
Homologous_superfamily	IPR008967	p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily	IPR012346	p53/RUNT-type transcription factor, DNA-binding domain superfamily
Homologous_superfamily	IPR027384	Runx, central domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:Q9DGB8	InterPro	451
UniProtKB:A0A8M9PJ75	InterPro	395
UniProtKB:A0AB32TPV4	InterPro	514
UniProtKB:A0AC58JES9	InterPro	451
UniProtKB:A0AC58JET2	InterPro	451
UniProtKB:A0AC58JET8	InterPro	514
UniProtKB:A0AC58JEU5	InterPro	451
UniProtKB:A0AC58JEU7	InterPro	451
UniProtKB:A0AC58JEV9	InterPro	451