ZFIN ID: ZDB-EXP-231107-6
Experiment Conditions Description: transection: caudal fin, chemical treatment by environment: atropine, chemical treatment by environment: numidargistat
transection: caudal fin
Name: transection
Synonyms:
Definition: Cutting transversly of an organ or tissue. Type of cutting often used to divide the spinal cord to investigate neural regeneration in zebrafish.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000181]
Name: caudal fin
Synonyms: tail, tail fin
Definition: Fin that is the most posterior median fin. It is composed of a complex of three modified centra and modified neural and hemal arches and spines.
Ontology: Anatomy Ontology [ZFA:0001058]
chemical treatment by environment: atropine
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: atropine
Synonyms: (+,-)-tropyl tropate, (+-)-atropine, (+-)-hyoscyamine, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate, [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate, Atropin, atropina, Atropine, dl-Hyoscyamine, dl-tropyltropate, rac-(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate, rac-tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate, tropine tropate
Definition: A racemate composed of equimolar concentrations of (S)- and (R)-atropine . It is obtained from deadly nightshade (Atropa belladonna) and other plants of the family Solanaceae.
Ontology: ChEBI [CHEBI:16684]  ( EBI )
chemical treatment by environment: numidargistat
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: numidargistat
Synonyms: (3R,4S)-1-L-alanyl-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid, (3R,4S)-3-amino-1-[(2S)-2-aminopropanoyl]-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid, CB 1158, CB-1158, CB1158, INCB 001158, INCB-001158, INCB001158, numidargistat, numidargistatum
Definition: An aminopyrrolidine that is pyrrolidine substituted by (2S)-2-aminopropanoyl, amino, carboxy, and 3-boronopropyl groups at positions 1, 3, 3, and 4 (the 3R,4S-stereoisomer). It is a selective arginase inhibitor being developed by Calithera Biosciences for the treatment of solid tumours.
Ontology: ChEBI [CHEBI:195556]  ( EBI )
Publication: Chen et al., 2022